ASCO 2024 | Evaluating the efficacy of obinutuzumab, ibrutinib, and venetoclax in Richter’s transformation
A lack of effective treatment options exists for patients with Richter’s transformation (RT). Tamar Tadmor, MD, Bnai Zion Medical Center, Haifa, Israel, discusses a Phase II non-randomized trial that investigated the efficacy of a triplet regimen of obinutuzumab, ibrutinib, and venetoclax in patients with RT (NCT04939363). The findings suggest that this chemotherapy-free regimen with a rapid venetoclax ramp-up may be a useful induction strategy prior to allogeneic stem cell transplantation (alloSCT) or CAR T-cell therapy in this patient population. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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