EHA 2024 | Selecting between BTK inhibitors in MCL & addressing resistance to these agents
Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, shares insights on choosing between BTK inhibitors (BTKi) for patients with mantle cell lymphoma (MCL) who progress on initial chemoimmunotherapy and discusses how to approach patients who develop resistance to these agents. Patients with relapsed/refractory (R/R) disease now have a variety of options, including ibrutinib, acalabrutinib, and pirtobrutinib. However, mechanisms of resistance to BTKis are complex and diverse in this disease setting. Prof. Danilov explains that CAR-T cells, such as brexucabtagene autoleucel (brexu-cel) and lisocabtagene maraleucel (liso-cel), and bispecific antibodies, such as glofitamab, may be considered for this patient population. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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