ASCO 2024 | Are BTK inhibitors a suitable treatment option for CLL with cardiovascular comorbidities?

Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, discusses using BTK inhibitors (BTKIs) for patients with chronic lymphocytic leukemia (CLL) with cardiovascular comorbidities. Although atrial fibrillation and hypertension are known side effects, Dr Shadman emphasizes that BTKIs can still be used, provided a comprehensive risk assessment is conducted with cardiologists. The choice of BTKI should be carefully considered in this patient subgroup, as current data suggest that rates of atrial fibrillation are lower with acalabrutinib and zanubrutinib than with ibrutinib. Based on findings from the ELEVATE-RR trial (NCT02477696), acalabrutinib is likely a better choice of BTKI than ibrutinib for patients with difficult-to-control hypertension. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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