Paul Richardson, MD, Dana-Farber Cancer Institute, Boston, MA, discusses mezigdomide, a novel cereblon E3 ligase modulator (CELMoD) under investigation in relapsed/refractory (R/R) multiple myeloma (MM). It has shown promise in treating triple-class refractory patients, and those with extramedullary disease. The response and durability of disease control are increased when mezigdomide is combined with other molecules such as dexamethasone, proteasome inhibitors, and antibodies. This interview took place at The 10th World Congress on Controversies in Multiple Myeloma (COMy) in Paris, France.
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